Table 3.
Risk prediction by individual and combined risk scores for CRC.
| Population | Predictor | AUC (95% CI) | Brier score |
|---|---|---|---|
| Prospective set (Ncases/controls = 198/178) | miR-score | Apparent: 0.808 (0.765–0.851); 0.632+: 0.794 | Apparent: 0.175; 0.632+: 0.184 |
| Prospective set participants with all scores available (Ncases/controls = 181/174) | ERS | 0.557 (0.498–0.616) | 0.248 |
| PRS | 0.622 (0.564–0.681) | 0.240 | |
| ERS + PRS | 0.631 (0.573–0.689) | 0.238 | |
| miR-score | Apparent: 0.815 (0.771–0.859); 0.632+: 0.802 | Apparent: 0.172; 0.632+: 0.181 | |
| ERS + miR-score | Apparent: 0.815 (0.771–0.859); 0.632+: 0.814 | Apparent: 0.172; 0.632+: 0.174 | |
| PRS + miR-score | Apparent: 0.824 (0.782–0.867); 0.632+: 0.822 | Apparent: 0.169; 0.632+: 0.171 | |
| ERS + PRS + miR-score | Apparent: 0.824 (0.781–0.867); 0.632+: 0.820 | Apparent: 0.169; 0.632+: 0.172 |
miR-score microRNA risk score, ERS environmental risk score, PRS polygenic risk score, CRC colorectal cancer, AUC area under the receiver-operating-characteristic curve, CI confidence interval.
Note– miR-score was derived in the overall prospective set (Ncases/controls = 198/178).