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. 2021 Aug 10;11:16205. doi: 10.1038/s41598-021-95761-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Study flow diagram. Three cohorts in the present study were divided as shown. In Cohort 1, 100 intervals were grouped as Mayo endoscopic subscore (MES) increase, no change, and decrease. In Cohort 2, groups of MES 0 or 1 and 2 or 3 were further subdivided as shown in the figure. In Cohort 3, 6 patients were excluded and the remaining 94 were grouped as sums of MES (S-MES) increase, no change, and decrease.