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. 2021 Aug 10;11:16210. doi: 10.1038/s41598-021-94594-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The levels of TNF-α, IL-6 and IL-1β in caco-2 cells after treated with different Danshen products. FDS47 (fermented Danshen sequence 47), FDS74 (fermented Danshen sequence 74), FDT47-sta (fermented Danshen together 47 shake), FDT47-sha (fermented Danshen together 47 stationary), Enz. (enzymolysis). TNF-α, IL-6 and IL-1β levels were examined in the supernatant of Caco-2 cells which were pretreated with 50 ug/mL LPS for 12 h, then treated with different Danshen products for 12 h or 24 h. All groups (Nor, FDS47, FDS74, FDT47-sta, FDT47-sha, Enz.) were statistically analyzed with the LPS group. Statistical analysis was conducted between FDS47 group and other groups (FDS74, FDT47-sta, FDT47-sha, Enz.). (Data are expressed as means ± S.E., *p < 0.05, **p < 0.01 and ***p < 0.001).