Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 10;12:4813. doi: 10.1038/s41467-021-25102-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a, b Quantifications showing the numbers of CD11c⁺Tbet⁺ ABCs (a) and CD11c⁺CD11b⁺ ABCs (b) from aged (24+wk) female C57BL/6 (WT; black circles), female DKO(F) (red circles), and female CD23-Cre.Tbx21^f/f.DKO (CD23-Tbx21.DKO(F)) mice (red open circles). Data show mean ± SEM; n = 6 for WT, n = 8 for DKO(F), n = 9 for CD23-Tbx21.DKO(F) over 6 independent experiments; p-value by 1-way ANOVA followed by Tukey’s test for multiple comparisons. c Plots showing the MFI of Fcrl5 and Cxcr3 on the surface of CD11c⁺CD11b⁺ ABCs (red) from the indicated mice. Non-GCBs (CD19⁺GL7⁻Fas⁻; gray) are shown as control. Data show mean ± SEM; n = 4; p-value by unpaired two-tailed t-tests. d–g Quantifications showing the numbers of total GL7⁺Fas⁺ B cells (d), total PB/PCs (e), CD11c⁺ GL7⁺Fas⁺ B cells (f), and CD11c⁺ PB/PCs (g) from the indicated aged (24+wk) mice. Data show mean ± SEM; n = 6 for WT, n = 8 for DKO(F), n = 9 for CD23-Tbet.DKO(F) over 6 independent experiments; p-value by 1-way ANOVA followed by Tukey’s test for multiple comparisons. h Quantifications showing the ratio of T_FH to T_FR cells ratio from the indicated mice. Data show mean ± SEM; n = 5 for WT, n = 7 for DKO(F), n = 8 for CD23-Tbet.DKO(F); p-value by 1-way ANOVA followed by Tukey’s test for multiple comparisons. i Pooled ELISA data of anti-dsDNA IgG1 and IgG2c levels in the serum from the indicated aged (24+wk) mice. Data show mean ± SEM; n = 5 for WT, n = 6 for DKO(F), n = 8 for CD23-Tbet.DKO(F); p-value by 1-way ANOVA followed by Tukey’s test for multiple comparisons.