Table 1.

Morphometric and echocardiographic characteristics of WT versus miR-106b~25 KO mice subjected to sham or TAC surgery for 4 weeks.

	Sham		TAC
	WT	KO	WT	KO
n	10	11	9	10
BW (g)	21.2 ± 0.2	21.3 ± 0.4	21.0 ± 0.5	21.0 ± 0.4
LV mass (mg)	107 ± 5	80 ± 5*	145 ± 12*	110 ± 8#
LV mass/BW (mg/g)	5.1 ± 0.3	3.8 ± 0.4*	7.1 ± 0.7*	5.3 ± 0.5#
IVSd (mm)	0.83 ± 0.05	0.68 ± 0.03*	1.04 ± 0.06*	0.89 ± 0.04#
IVSs (mm)	1.16 ± 0.06	1.04 ± 0.03	1.40 ± 0.07*	1.16 ± 0.05#
LVIDd (mm)	4.09 ± 0.08	4.15 ± 0.09	4.10 ± 0.14	4.41 ± 0.11
LVIDs (mm)	2.87 ± 0.08	3.14 ± 0.08	3.14 ± 0.07	3.61 ± 0.15*#
LVPWd (mm)	0.89 ± 0.04	0.65 ± 0.04*	1.04 ± 0.06*	0.70 ± 0.05*#
LVPWs (mm)	1.11 ± 0.05	0.83 ± 0.03*	1.30 ± 0.08*	0.88 ± 0.05*#
EF (%)	64 ± 1	57 ± 1*	54 ± 2*	45 ± 3*#
FS (%)	29 ± 1	25 ± 1*	23 ± 1*	18 ± 1*#
E/A (mm/s)	1.73 ± 0.11	1.53 ± 0.10	1.62 ± 0.10	1.57 ± 0.24*

Data are expressed as means ± SEM.

BW body weight, LV left ventricular, IVSd interventricular septal thickness at end-diastole, IVSs interventricular septal thickness at end-systole, LVIDd left ventricular internal dimension at end-diastole, LVIDs left ventricular internal dimension at end-systole, LVPwd left ventricular posterior wall thickness at end-diastole, LVPws left ventricular posterior wall thickness at end-systole, EF ejection fraction, FS fractional shortening, E/A Doppler E/A ratio.

*Indicates P < 0.05 vs sham group subjected to treatment with a control antagomir.

^#Indicates P < 0.05 vs experimental group.