Table 1.
Participant demographic, cognitive, and clinical data.
| WMH− | WMH + | p value | |
|---|---|---|---|
| Total number | 15 | 11 | – |
| Female, % total (N) | 40 (6) | 45 (5) | 0.50 |
| Age, mean years (SEM) | 72 (2) | 80 (2) | 0.0003 |
| Education, mean years (SEM) | 18 (.5) | 18 (.6) | 0.90 |
| CDR | 0 | 0 | – |
| MMSE, mean (SEM) | 29 (.2) | 29 (.3) | 0.60 |
| Processing speed, s (SEM) | 21(6) | 34 (14) | 0.007 |
| Systolic blood pressure, mmHg (SEM) | 130 (3) | 150 (6) | 0.0005 |
| Diastolic blood pressure, mmHg (SEM) | 68 (2) | 69 (2) | 0.70 |
| Low density lipoprotein, mg/dL (SEM) | 125 (12) | 93 (18) | 0.10 |
| High density lipoprotein, mg/dL (SEM) | 65 (4) | 59 (6) | 0.40 |
| Triglycerides, mg/dL (SEM) | 69 (9) | 85 (19) | 0.40 |
| Hemoglobin A1C, % (SEM) | 5.5 (0.06) | 5.7 (0.3) | 0.40 |
| Insulin, mg/dL (SEM) | 8 (1) | 8 (2) | 0.90 |
| HOMA-IR, US Stanford Units (SEM) | 1.9 (0.2) | 2.1 (0.5) | 0.60 |
Two-tailed Student’s t-tests or the non-parametric Wilcoxon rank sum were used for statistical comparison of continuous measures and Chi-squared tests were performed to compare group characteristics. Results are included in this table. Age, systolic blood pressure, and processing speed were the only significant different variables between groups.