Table 4.

Relationship between EDE complement proteins and clinical factors.

Molecules	Systolic blood pressure						White matter hyperintensity						Processing speed
	R2 adjusted	Prob > F	AICc	BIC	Beta	p-value	R2 adjusted	Prob > F	AICc	BIC	Beta	p-value	R2 adjusted	Prob > F	AICc	BIC	Beta	p-value
C1q	0.53	0.0006	38	39	0.46	0.05	0.45	0.0008	155	157	0.40	0.05	0.21	0.05	23	25	0.59	0.05
C4b	0.06	0.60	43	44	0.08	0.80	0.33	0.006	159	162	0.08	0.70	0.04	0.60	29	31	0.08	0.70
C3b	0.32	0.01	46	48	0.31	0.20	0.62	< 0.0001	146	149	0.65	0.001	0.03	0.30	28	29	0.33	0.20
C5b-9	0.33	0.01	33	34	0.20	0.40	0.56	< 0.0001	149	152	0.64	0.005	0.04	0.60	29	31	0.13	0.70
Bb	0.52	0.0008	53	54	0.58	0.02	0.47	0.0005	153	156	0.40	0.03	0.37	0.006	18	20	0.71	0.005
Factor B	0.08	0.20	48	50	0.41	0.10	0.57	0.001	149	151	0.52	0.004	0.02	0.50	29	30	0.17	0.50
Factor D	0.01	0.90	28	30	0.02	0.90	0.37	0.003	158	160	0.22	0.20	0.05	0.60	29	31	0.05	0.80
CD59	0.43	0.003	58	59	− 0.62	0.02	0.36	0.003	158	161	− 0.21	0.20	0.14	0.10	25	27	− 0.48	0.06
Factor I	0.10	0.16	40	41	− 0.60	0.07	0.33	0.006	159	162	− 0.09	0.60	0.15	0.09	25	26	− 0.44	0.10
CR1	0.06	0.60	35	36	− 0.17	0.60	0.32	0.007	160	162	0.05	0.80	0.03	0.30	28	29	− 0.28	0.20
DAF	0.07	0.20	15	17	− 0.49	0.09	0.37	0.003	158	161	− 0.21	0.20	0.08	0.20	26	28	− 0.35	0.10
CD46	0.004	1.0	36	37	− 0.05	0.90	0.32	0.007	160	162	0.01	1.0	0.001	0.40	28	30	− 0.22	0.30
MBL	0.06	0.20	50	51	− 0.44	0.10	0.32	0.007	160	162	0.006	1.0	0.02	0.30	28	29	− 0.27	0.20

Illustrated in this table are results of standard least square models with: (1) systolic blood pressure as independent variable and complement factors as dependent; (2) complement factors as independent and global volume of white matter hyperintensity as dependent; (3) complement factors as independent and cognitive processing speed (based on time taken to complete the modified Trails test) as dependent. Age was adjusted for in all models. All p-values are FDR-corrected for multiple comparisons.