Table 2.
Small molecules and drugs that interfere with ferroptosis in AS-related cells.
| Compound | Cell type | Treatment effects | References |
|---|---|---|---|
| Erastin | HUVEC | Induce ferroptosis with a rapid generation of ROS and a reduced viability | [76] |
| MAEC | Induce ferroptosis with elevated ROS, lipid peroxidation, and MDA levels within the damaged mitochondria | [12] | |
| RSL3 | Macrophage | Induce ferroptosis associated with inducible NO synthase/NO• | [88] |
| Fer-1 | HUVEC | Allevite ROS and maintain cell viability | [76] |
| MAEC | Suppress the generation of peroxidation products | [12] | |
| DFO | Macrophage | Decreasing the macrophage markers and lowering proinflammatory factor MCP-1 in apoE−/− mice | [95] |
| Deferoxamine Mesylate | HUVEC | Rescued ferroptotic damage in endothelial cells | [77] |
| CSE | VSMC | Induced ferroptosis and upregulate atherosclerotic inflammatory factors | [11] |