Table 2.

List of the predicted SUMOylation sites^*.

Protein symbol	Uniprot ID	Sub-organelle localization	SUMOylation sites	P-value	Pathophysiological function
PPAR-γ	P37231	nuclear compartment	QEYQSAIK107VEPASPP FGDFMEPK395FEFAVKF	0.000 0.037	Suppress apoptotic and inflammatory injury
HDAC4	P56524	nuclear compartment	AQAGVQVK559QEPIESD	0.001	Enhance the survival of cardiomyocytes
SIRT1	Q96EB6	nuclear compartment	INEAISVK734QEVTDMN DEPLAIMK408PEIVFFG EQFHRAMK427YDKDEVD DMNYPSNK746S	0.004 0.014 0.042 0.049	Enhance the myocardial cell Adaption to genotoxic stress; Regulate cardiac metabolism
FXR	P51114	nuclear compartment	LPPPPDIK56KEISEGD EEKINTLK607EENTQEA LAKVRMMK88GEFYVIE	0.005 0.006 0.026	Modulate the adverse cardiac effects of FXR
HIF-1α	Q16665	nuclear compartment	SSLFDKLK391KEPDALT LNQEVALK477LEPNPES SDMVNEFK532LELVEKL	0.002 0.003 0.026	Lead to the degradation of HIF-1α
SERCA2a	P16615	sarcoplasmic reticulum membrane	SVIKQLMK480KEFTLEF EDSANFIK585YETNLTF	0.004 0.005	Enhance intracellular mitochondrial membrane potential and reduce cell apoptosis
Drp1	O00429	mitochondria	RGMLKTSK597AEELLAE	0.072	Increase mitophagy; prevent ROS generation and cell death

^*The prediction was carried out by Software GPS-SUMO (http://sumosp.biocuckoo.org/).