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. 2021 Aug 10;12:4840. doi: 10.1038/s41467-021-25122-4

Fig. 5. Development of a response prediction model for 5-FU-based chemotherapy.

Fig. 5

a The gene expression of 30 classifier genes from among the core DEGs in PDX tumors. bd Survival analyses for GC patients in ACRG (b), TCGA (c), and Singapore-Duke (d) studies, according to prediction model. Patients were stratified by our prediction model, and the responder-like (R-like) patient group showed a significantly better prognosis than the non-responder-like (NR-like) group. P values were calculated from the log-rank test. ACRG the Asian Cancer Research Group. eg Reassignment of GC patients from the ACRG study (e), TCGA (f), and Singapore-Duke (g) studies according to prediction model (Top). Survival analyses for subgroups in ACRG (e), TCGA (f), and Singapore-Duke (g) studies, according to prediction model (bottom). P values were calculated from the two-sided log-rank test.