. 2021 Feb 22;30(10):847–864. doi: 10.1093/hmg/ddab054

Table 1.

Fold changes of mRNA expression of mitochondrial structural, synaptic, biogenesis, autophagy and mitophagy genes in mutant APP-HT22 cells compared with HT22 cells and also citalopram-treated mutant APP-HT22 cells compared with citalopram-untreated mutant APP-HT22 cells

	Genes	mRNA fold changes	mRNA fold change
	Genes	HT22 versus HT22 + mAPP	HT22 + mAPP versus HT22 + mAPP+Cit
Mitochondrial structural genes	Drp1	2.1^**	-2.5^**
	Fis1	1.7^*	-2.2^**
	Mfn1	-1.8^*	2.0^*
	Mfn2	-2.2^*	2.7^*
	OPA1	-1.9	2.1^*
Synaptic genes	Synaptophysin	-2.2^**	2.7^**
Synaptic genes	PSD95	-2.1^**	2.0^*
Serotonin-related genes	SERT	-2.4	1.9^**
	TPH 2	-2.1^**	3.4^*
	5HTR1A	-2.0^*	1.8^*
	5HTR1B	-2.1	2.8
	5HTR4	-2.7	3.7^*
	5HTR6	2.1	-2.1
Biogenesis genes	Nrf1	-1.8^*	2.3
	PGC1α	-2.1^**	3.1^**
	Nrf2	-1.6^*	2.3^*
	TFAM	-2.5^**	3.1^*
Autophagy genes	LC3A	-1.6^*	2.3^*
	LC3B	-1.8^*	2.5^*
	ATG5	-2.5	2.4^*
	Beclin1	-1.5^*	2.2^*
Mitophagy genes	TERT	-2.1^**	3.5^*
	PINK1	-2.4^**	2.0^*
	BCL2	-1.5^*	2.1^*
	BNIP3L	-1.3	2.7^*
AD genes	MAPT	2.8^*	-2.8
	APP	2.1	-2.3^*
	BACE1	2.7	-2.4^*
	ADAM10	-2.1^*	3.2^*

^*P < 0.05.

^**P < 0.005.