Table 2.

The indications, contraindications, side effects, and application instructions of CrP supplement for IHD.

Indications	Contraindications and relative contraindication	Side effects	Instructions of administration and dosage
• Cardiac metabolic abnormalities during myocardial ischemia. • Cardioprotection during heart surgery.	• Chronic renal failure (in high doses, for example, daily dose of 5–10 g). • Hypersensitivity to drug components. • Pregnancy.	• Allergic reactions. • Lowering of arterial pressure.	• Cardiac metabolic abnormalities during myocardial ischemia: 0–24 h—intravenous bystry infusion of 2–4 g of CrP divorced in water for injections of 50 ml with the subsequent intravenous infusion for 2 h 8–16 g in 250 ml of 5% of solution of glucose; during second day 2 times a day intravenously kapelno (infusion duration of 30 min) enter 2–4 g of the drug divorced in 50 ml of water for injections; during third day the drug is administered according to the same scheme in a dose 2 g (if necessary treatment is continued for 6 days). • Cardioprotection during heart surgery: intravenously kapelno (infusion duration of 30 min) 2 g of the drug divorced in 50 ml of water for injections with frequency rate of introduction 2 times a day. The course is begun in 3–5 days prior to surgical intervention and continued 1–2 more days after its carrying out. During operation it is necessary to add to composition of usual cardioplegic solution in concentration 10 mmol/l just before introduction.

CrP, creatine phosphate; IHD, ischemic heart disease.