TABLE 1.

Effects of sex, GDX, and diet on various metabolic parameters.

	B	p value	95.0% Confidence interval
			Lower bound	Upper bound
Cumulative intake (calorie)
Female vs Male#	–13.234	0.298	–38.542	12.075
GDX vs Sham##	7.461	0.554	–17.798	32.721
High fat diet vs Regular chow###	56.660	p< 0.001***	31.306	82.013
Body weight change (g)
Female vs Male#	–0.448	0.620	–2.255	1.359
GDX vs Sham##	0.532	0.556	–1.275	2.339
High fat diet vs Regular chow###	5.389	p< 0.001***	3.582	7.196
Blood glucose change (mg/dL)
Female vs Male#	13.141	0.128	–3.915	30.198
GDX vs Sham##	1.143	0.893	–15.913	18.200
High fat diet vs Regular chow###	37.838	p< 0.001***	20.782	54.894
Fat change (g)
Female vs Male#	–2.052	0.012*	–3.633	–0.471
GDX vs Sham##	1.495	0.063	–0.085	3.076
High fat diet vs Regular Chow###	5.539	p< 0.001***	3.958	7.120
P for the interaction of Sex and Diet		0.226
Lean change (g)
Female vs Male#	1.405	p< 0.001***	0.828	1.983
GDX vs Sham##	–0.805	0.007**	–1.383	–0.228
P for the interaction of Sex and GDX		p< 0.001***
High fat diet vs Regular chow###	–0.107	0.710	–0.684	0.470

^#Here we use male mice as reference. ^##Here we use sham mice as reference. ^###Here we use regular chow as reference. B stands for regression coefficients. The p value is the smallest level α0 such that we would reject the null-hypothesis at level α0 with the observed data. The confidence interval (CI) is a range of values that’s likely to include a population value with a certain degree of confidence. *p < 0.05, **p < 0.01, ***p < 0.001.