Table 4.

Characteristics of the secondary metabolites derived from microorganisms used for cervical cancer treatment.

	Origin	Anti-tumor mechanism	Reference
Rosoloactone	Trichothecium roseum	Rosoloactone mediates pro-apoptotic effects via the activation of ERS-associated apoptosis and the mitochondria-mediated apoptotic pathway.	(56)
PSE	Penicillium sclerotiorum	PSE leads to activation of mitochondrial pathway of apoptosis and exhibites both antioxidant and anti-angiogenic properties.	(57)
Streptomyces sp metabolite(s)	Streptomyces sp OA293	A mTORC1 inhibitor suppresses activation of both of its downstream targets, 4E-BP1 and P70S6k and Akt expression	(58)
Polysaccharides	Enterobacter cloacae	Induce the apoptosis of cervical cancer cells through an intrinsic apoptotic pathway	(59)
Gliotoxin	Aspergillus sp	Induce apoptosis in Hela and SW1353 cells via the mitochondrial pathway	(60)