FIGURE 2.

Longitudinal evaluation of RGC activity using PERG. PERG responses were recorded before the beginning of the treatment (A) and after 1 (B) or 2 (C) months of treatment in D2 (black traces) and D2+LG (red traces) mice. PERG responses were analyzed by retrieving the peak-to-trough amplitude and time-to-peak latency, as shown in the inset in (A). The distribution of PERG amplitudes (D) and PERG latencies (E) in D2 (white boxes) and D2+LG (dashed boxes) deriving from n = 6 mice are shown by box plots. Statistical differences were tested using two-way ANOVA with Bonferroni post-hoc test. *p < 0.05, **p < 0.01, ***p < 0.001.