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. 2021 Jul 28;12:719951. doi: 10.3389/fphar.2021.719951

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Copyright © 2021 Amato, Rossino, Cammalleri, Timperio, Fanelli, Dal Monte, Pucci and Casini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) densitometric analysis of GFAP immunostaining in central and peripheral areas of D2 (white box) and D2+LG (dashed boxes). (B) correlation of GFAP immunofluorescence levels with the correspondent RGC density per optical filed in central and peripheral retinal areas. (C) ratio between GFAP immunostaining and RGC density in central and peripheral retinal areas of D2 (white box) and D2+LG (dashed boxes) mice. Box plots describe the statistical distribution of n = 4 independent retinas. Data were analyzed using two-way ANOVA with Bonferroni post-hoc test. **p < 0.01, ***p < 0.001.