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. 2021 Jul 28;8:607886. doi: 10.3389/fmolb.2021.607886

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Copyright © 2021 Malik, Kumar, Ansari, Hemida, El Zowalaty, Abdel-Moneim, Ganesh, Salajegheh, Natesan, Sircar, Safdar, Vinodhkumar, Duarte, Patel, Klein, Rahimi and Dhama.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic genomic organization of the full length spike glycoprotein of SARS-CoV-2. The surface spike protein contains S1 and S2 domain. At the N terminal, S1 domain consists of a signal sequence (SS) which is followed by N-terminal domain (NTD; 293 amino acids) and Receptor Binding Domain (RBD; 222 amino acids). S2 domain consists of fusion peptide (FP) followed by two heptad repeats (HR1 and HR2), a central helix (CH), a connector domain (CD), a transmembrane domain (TM) and the cytoplasmic tail (CT).