Table 3.

Serum chemistry profiles for dogs on day 0 and 49 of study

Item	Reference range1	Day 0	Day 49	SEM	P-value
Creatinine, mg/dL	0.5-1.5	1.00	1.01	0.042	0.33
Blood urea nitrogen, mg/dL	6-30	16.68	16.77	0.910	0.88
Total protein, g/dL	5.1–7.0	6.03a	6.27b	0.065	<0.0001
Albumin, g/dL	2.5–3.8	3.08a	3.23b	0.039	<0.0001
Globulin, g/dL	2.7–4.4	2.95a	3.04b	0.049	0.05
Albumin:globulin ratio	0.6–1.1	1.05	1.07	0.020	0.18
Calcium, mg/dL	7.6–11.4	9.95a	10.13b	0.076	<0.0001
Phosphorus, mg/dL	2.7–5.2	3.82	3.86	0.089	0.67
Sodium, mmol/L	141–152	145.66b	144.52a	0.263	<0.0001
Potassium, mmol/L	3.9–5.5	4.41a	4.66b	0.040	<0.0001
Sodium:potassium	28–36	33.18b	31.14a	0.318	<0.0001
Chloride, mmol/L	107–118	114.20b	112.48a	0.325	<0.0001
Glucose, mg/dL	68–126	100.43b	92.27a	1.855	<0.01
ALP2, U/L	7–92	102.00	123.20	23.406	0.33
CALP3, U/L	0–40	64.05	80.91	19.781	0.02
ALT4, U/L	8–65	47.30	52.19	5.834	0.29
GGT5, U/L	0–7	3.36	3.04	0.266	0.16
Total bilirubin, mg/dL	0.1–0.3	0.24a	0.27b	0.015	0.04
Cholesterol, mg/dL	129–297	238.38a	259.84b	8.497	<0.0001
Triglycerides, mg/dL	32–154	85.84	98.61	13.336	0.42
Bicarbonate, mmol/L	16–24	20.64	20.98	0.321	0.35

¹Reference ranges were provided from the University of Illinois Veterinary Diagnostic Lab.

²ALP, alkaline phosphatase.

³CALP, corticosteroid-induced alkaline phosphatase.

⁴ALT, alanine aminotransferase.

⁵GGT, gamma-glutamyl transferase.

^a,

^bWithin a row, means with different superscripts differ (P < 0.05).