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. 2021 Jul 28;9:667765. doi: 10.3389/fcell.2021.667765

FIGURE 3.

FIGURE 3

Cells and factors involved in ESG regeneration and their relationships. Stem cells are often used in the study of wound repair and regeneration of various tissues due to their ability to self-renew and differentiate into multiple lineages. To date, eight types of cells have been reported to have the potential to regenerate ESGs (Shikiji et al., 2003; Li et al., 2006, 2015b; Nolte et al., 2008; Sheng et al., 2009; Vierbuchen et al., 2010; Lu et al., 2012; Xu et al., 2012, 2016; Wang et al., 2013, 2019; Hassan et al., 2014; Tao et al., 2014; Liang et al., 2016; Kolakshyapati et al., 2017; Sun et al., 2018; Yao et al., 2018, 2019, 2020; Chen et al., 2019; Hu et al., 2019). Cytokines and growth factors play a role in inducing cells directed to differentiate into sweat gland-like cells during the process of ESG regeneration, and the discovery of these factors involves research on the determination and development of ESGs (Shikiji et al., 2003; Cai et al., 2011; Zhao et al., 2015; Liang et al., 2016; Xu et al., 2016; Kolakshyapati et al., 2017; Sun et al., 2018; Yao et al., 2018, 2019, 2020; Chen et al., 2019; Hu et al., 2019; Wang et al., 2019). Selecting appropriate cells and appropriate factors to induce the differentiation of sweat gland-like cells makes the regeneration of ESGs possible.