Table 1.
Characteristics of included studies.
| Study | Subject of project | Type of cancer | High-throughput technology | Source of microbiota |
|---|---|---|---|---|
| Zheng et al. (2011) | Human | Gastrointestinal cancers | Pyrosequencing | Formalin fixed and paraffin-embedded (FFPE) Biopsies |
| Zwielehner et al. (2011) | Human | Cancer* | 16S rRNA | Fecal microbiota |
| Ganzenmueller et al. (2013) | Human | Verrucous skin tumors | Pyrosequencing | Virus |
| Gilbreath et al. (2013) | Human | Peritoneal tumors | 16S rRNA | Tumor tissue |
| Hu et al. (2013a) | Human | Head and neck cancers | Pyrosequencing | Supragingival plaque |
| Hu et al. (2013b) | Human | Head and neck cancers | 16S rRNA | Oral microbiota |
| Weir et al. (2013) | Human | Colorectal cancer | 16S rRNA | Stool microbiome |
| Yamamoto et al. (2013) | Mice | Lymphoma | 16S rRNA | Intestinal bacteria |
| Dejea et al. (2014) | Human | Colorectal cancers | 16S rDNA | Colon tissues |
| Eun et al. (2014) | Human | Gastric cancer | 16S rRNA | Gastric mucosal microbiota |
| Liang et al. (2014) | Mice | Colorectal cancer | 16S rRNA | Gut microbiome |
| Montassier et al. (2014) | Human | Non-hodgkin's lymphoma | 16S rRNA | Fecal microbiota |
| Wang et al. (2014) | Human | Leukemia | 16S rRNA | Oral microbiota |
| Zackular et al. (2014) | Human | Colorectal cancer | 16S rRNA | Gut microbiome |
| Hu et al. (2015) | Human | Gastric cancer | 16S rDNA | Tongue coating microbiota |
| Pal et al. (2015) | Human | Metastatic renal cell carcinoma | 16S rRNA | Stool bacteriomic |
| Montassier et al. (2015) | Human | Non-hodgkin's lymphoma | 16S rRNA | Intestinal microbiome |
| Torres et al. (2015) | Human | Pancreatic cancer | 16S rRNA | Salivary microbiome |
| Gao et al. (2015) | Human | Head and neck cancer | Pyrosequencing | Oral microbiota |
| Shelburne et al. (2015) | Human | Leukemia | 16S rRNA; ITS sequencing | Oral and stool microbiome and mycobiome |
| Kasai et al. (2016) | Human | Colorectal carcinoma | 16S rDNA | Gut microbiota |
| Galloway-Peña et al. (2016) | Human | Acute myeloid leukemia | 16S rRNA | Gastrointestinal microbiome |
| Audirac-Chalifour et al. (2016) | Human | Cervical cancer | 16S rDNA | Cervical microbiome |
| Montassier et al. (2016) | Human | Non-hodgkin lymphoma | 16S rRNA | Gut microbiome |
| Walther-António et al. (2016) | Human | Endometrial cancer | 16S rDNA | Uterine microbiome |
| Harris et al. (2016) | Human | Leukemia | 16S rRNA | Gut microbiota |
| Thomas et al. (2016) | Human | Rectal carcinoma | 16S rRNA | Fecal samples |
| Chng et al. (2016) | Human | Cholangiocarcinoma | 16S rRNA | Tissue microbiome |
| Lu et al. (2016) | Human | Liver carcinoma | 16S rRNA | Tongue coat microbiome |
| Moen et al. (2016) | Mice | Colorectal cancer | 16S rRNA | Cecal microbiota |
| Lee et al. (2016) | Human | Lung cancer | 16S rRNA | Microbiome in bronchoalveolar lavage |
| Salava et al. (2016) | Human | Melanomas | 16S rRNA | Skin microbiome |
| Zhu et al. (2017) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Wolf et al. (2017) | Human | Oropharyngeal squamous cell carcinoma | 16S rRNA | Salivary microbiome |
| Banerjee et al. (2017) | Human | Ovarian cancer | PathoChip microarray; Capture-next generation sequencing | FFPE samples |
| Frankel et al. (2017) | Human | Melanoma | Metagenomics | Gut microbiota |
| Gong et al. (2017) | Human | Laryngeal carcinoma | Pyrosequencing | Tumor tissues |
| Cavarretta et al. (2017) | Human | Prostate tumor | Pyrosequencing | Tumor tissues |
| Wang et al. (2017) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Yu T. et al. (2017) | Human | Colorectal cancer | 16S rDNA | Gut microbiota |
| Yu J. et al. (2017) | Human | Colorectal cancer | Metagenomics | Fecal microbiome |
| Bučević Popović et al. (2018) | Human | Bladder cancer | 16S rRNA | Urinary microbiome |
| Cong et al. (2018) | Human | Colorectal cancer | 16S rRNA | Gut microbiota |
| Hakim et al. (2018) | Human | Acute lymphoblastic leukemia | 16S rRNA | Gut microbiome |
| Herstad et al. (2018) | Dog | Colorectal epithelial tumors | 16S rRNA; 16S rDNA | Fecal and mucosaassociated microbiota |
| Kwasniewski et al. (2018) | Human | Cervical cancer | 16S rRNA | Cervical microbiota |
| Loke et al. (2018) | Human | Colorectal cancer | 16S rRNA | Colon tissues |
| Meng et al. (2018) | Human | Breast cancer | 16S rRNA | Breast tissue |
| Perera et al. (2018) | Human | Oral squamous cell carcinoma | 16S rRNA | Oral fibroepithelial polyp |
| Stojanovska et al. (2018) | Mice | Colorectal cancer | 16S rRNA | Fecal microbiota |
| Sun et al. (2018) | Human | Gastric cancer | 16S rRNA | Oral microbiome |
| Wang et al. (2018) | Mice | Colorectal cancer | 16S rRNA | Feces samples and intestinal tissues |
| Wu et al. (2018) | Human | Bladder cancer | 16S rRNA | Urinary microbiota |
| Xue et al. (2018) | Rats | Breast cancer | 16S rDNA | Intestinal flora |
| Yuan et al. (2018) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Zhang et al. (2018) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Fan et al. (2018) | Human | Pancreatic cancer | 16S rRNA | Oral microbiome |
| Dai et al. (2018) | Human | Colorectal cancer | Metagenomics | Fecal microbiome |
| DeFilipp et al. (2018) | Human | Acute myeloid leukemia; myelodysplastic syndrome; non-hodgkin lymphoma | 16S rRNA | Fecal microbiota |
| Gopalakrishnan et al. (2018) | Human | Melanoma | 16S rRNA | Gut microbiome |
| Shah et al. (2018) | Human | Colorectal cancer | 16S rRNA | Fecal microbiome |
| Routy et al. (2018) | Human | Epithelial tumors | Metagenomics | Gut microbiome |
| Matson et al. (2018) | Human | Metastatic melanoma | 16S rRNA, metagenomics | Commensal microbiome |
| Ai et al. (2019) | Human | Colorectal cancer | Metagenomics | Gut microbiota |
| Alanee et al. (2019a) | Human | Prostate cancer | 16S rRNA | Urinary and fecal microbiota |
| Alanee et al. (2019b) | Human | Suspected prostate cancer | 16S rRNA | Urinary microbiome |
| Cho et al. (2019) | Human | Hepatocellular carcinoma | 16S rDNA | Fasting serum samples |
| Cong et al. (2019) | Human | Colorectal cancer | 16S rRNA | Intestinal microbiota |
| Diaz et al. (2019) | Human | Solid tumor | 16S rRNA; ITS-1 DNA | Saliva |
| Han et al. (2019) | Human | Colorectal cancer | 16S rRNA | Intestinal microorganisms |
| Ibrahim et al. (2019) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Jiang et al. (2019) | Human | Nasopharyngeal carcinoma | 16S rDNA | Intestinal microbiota |
| Klein et al. (2019) | Human | Cervical cancer | 16S rRNA | Cervical microbiome |
| Kong et al. (2019) | Human | Colorectal cancer | 16S rRNA | Intestinal microbiota |
| Leung et al. (2019) | Human | Colorectal cancer | 16S rRNA | Colonic microbiota |
| Liang et al. (2019) | Human | Gastric cancer | 16S rRNA | Gut microbiota |
| Mai et al. (2019) | Human | Bladder cancer | 16S rRNA | Urine bacteria |
| Ni et al. (2019) | Human | Primary hepatocellular carcinoma | 16S rRNA | Gut microbiota |
| Qi et al. (2019) | Mice | Hepatocellular carcinoma | 16S rDNA | Gut microbiota |
| Wang K. et al. (2019) | Human | Primary bronchogenic carcinoma | 16S rDNA | Saliva and bronchoalveolar lavage fluid samples |
| Wang L. et al. (2019) | Human | Throat cancer | 16S rRNA | Oral microbiota |
| Wongsurawat et al. (2019) | Human | Head and neck cancer | Metagenomics | Gut microbiome |
| Wu M. et al. (2019) | Mice | Colorectal cancer | 16S rDNA; 18S rRNA | Gut microbes |
| Wu Y. et al. (2019) | Human | Colorectal cancer | 16S rRNA | Colorectal cancer tissues |
| Xu et al. (2019) | Human | Gastric cancer | 16S rDNA; 18S rRNA | Tongue coatings |
| Yang et al. (2019) | Human | Colorectal cancer | 16S rRNA | Gut microbiota |
| Zhang B. et al. (2019) | Human | Multiple myeloma patients | 16S rRNA | Fecal microbiota |
| Zhang L. et al. (2019) | Human | Primary liver cancer | 16S rDNA | Gut microbes |
| Zheng et al. (2019) | Human | Gastric cancer | 16S rDNA | Gastric juice or feces |
| Zhou et al. (2019) | Human | Ovarian carcinoma | 16S rRNA | Ovarian cancer tissues |
| Feng et al. (2019) | Human | Prostate cancer | Metagenomic; Metatranscriptomics | Prostate microbiota |
| Peters et al. (2019) | Human | Melanoma | 16S rRNA; metagenomics; metatranscriptome | Gut microbiome |
| Bian et al. (2020) | Mice | Colon cancer | 16S rRNA | Gut microbiota |
| Clos-Garcia et al. (2020) | Human | Colorectal cancer | Metagenomics | Fecal metagenomics |
| Erawijantari et al. (2020) | Human | Gastric cancer | 16S rRNA | Fecal microbiome |
| Ji et al. (2020) | Mice | Colorectal cancer | Metagenomics | Gut microbiota |
| Zhang Z. et al. (2020) | Mice | Colorectal cancer | 16S rRNA | Gut bacteria |
| Zeng et al. (2020) | Human | Bladder cancer | 16S rRNA | Urinary microbiome |
| Yu et al. (2020) | Mice | Colorectal cancer | 16S rRNA | Gut microbiota |
| Xie et al. (2020) | Human | Cervical cancer | 16S rDNA | Vaginal microbiota |
| Wei et al. (2020) | Human | Pancreatic cancer | 16S rRNA | Oral microbiome |
| Wang W. J. et al. (2020) | Human | Colorectal adenoma | 16S rDNA | Intestinal microflora |
| Wang, Q. et al. (2020) | Human | Colorectal cancer | 16S rRNA | Gut mucosal microbiome |
| Sun et al. (2020) | Human | Pancreatic cancer | 16S rDNA | Oral microbiome |
| Song and Gyarmati (2020) | Mice | Pediatric acute lymphocytic leukemia | 16S rDNA | Gut microbiota |
| Shen et al. (2020) | Rats | Colorectal cancer | 16S rDNA | Gut microbiota |
| Moskowitz et al. (2020) | Mice | Colorectal cancer | 16S rRNA; metagenomics | Gut microbiota |
| Kim et al. (2020) | Human | Hepatocellular carcinoma | 16S rRNA | Serum extracellular vesicles |
| Kang et al. (2020) | Human | Invasive cervical cancer | 16S rRNA | Fecal microbiota |
| Hu et al. (2020) | Mice | Melanoma | 16S rDNA | Intestinal microbiota |
| Chou et al. (2020) | Mice | Colorectal cancer | 16S rRNA | Gut microbiome |
| Li et al. (2020) | Human | Liver cancer | 16S rDNA | Oral microbiota |
| Liu M. et al. (2020) | Mice | Colon cancer | 16S rRNA | Gut microbiota |
| Pan et al. (2020) | Rats | Esophageal tumorigenesis | 16S rRNA | Gut microbiota |
| Heshiki et al. (2020) | Human | Lung cancer | Metagenomics | Gut microbiota |
| Nejman et al. (2020) | Human | Seven cancer types | 16S rRNA; 16S rDNA | Tumor microbiome |
| Peled et al. (2020) | Human | Hematologic cancers | 16S rRNA | Intestinal microbiota |
| Chung et al. (2021) | Human | Pancreatic cancer | 16S rRNA | Oral, intestinal, and pancreatic bacterial microbiomes |
| Debesa-Tur (2021) | Human | Colorectal cancer | Metagenomics | Ffpe tissue |
| Jiang and Fan (2021) | Mice | Breast cancer | 16S rDNA | Intestinal microbiota |
| Baruch et al. (2021) | Human | Melanoma | 16S rRNA | Gut microbiota |
*
Seventeen subjects receiving ambulant chemotherapy with antimicrobial therapy.