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. 2021 Jul 28;8:708644. doi: 10.3389/fmed.2021.708644

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Copyright © 2021 Xu, Li, Chen, Li, Wu, Zhang, Cui and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The Association Between MTMR3 Gene Expression and Breast Cancer. (A) MTMR3 is highly expressed in normal tissues compared to primary tumor tissues (p <1E-12). (B) MTMR3 promoter is hypermethylated in primary tumor tissues compared to normal tissues (p = 2.66E-02). The Beta value indicates level of DNA methylation ranging from 0 (unmethylated) to 1 (fully methylated). (C) MTMR3 gene expression has no correlation with the overall survival of breast cancer patients (p =0.44). (D) Lower expressed MTMR3 could reduce patient's relapse free survival (RFS) (p =2.2E-06) (KIAA0371 202197_at).