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. 2021 Jul 28;12:732540. doi: 10.3389/fphar.2021.732540

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Copyright © 2021 Liu, Ding, Hou, Yu, Nie and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-130a-3p in BMSCs regulates fibrogenesis of MLg induced by TGF-β1 by inhibiting the function of TGF-βRII. (A) Representative Western blot bands of α-SMA, FN, TGF-βRII, Smad2/3 and p-Smad2/3 protein expression in BMSCs transfected with NC or miR-130a-3p mimic, followed by co-cultured with MLg. (B–E) The statistical analysis of the above-mentioned proteins was obtained from the relative gray values of the protein bands (α-SMA/β-actin, FN/β-actin, TGF-βRII/β-actin, p-Smad2/3/Smad2/3). Data were presented as mean ± SE, ^** p < 0.01, ^*** p < 0.001, compared with NC group. ^& p < 0.05, ^&& p < 0.01, compared with NC + TGF group. n = 3–4.