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. 2021 Jul 28;12:732540. doi: 10.3389/fphar.2021.732540

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Copyright © 2021 Liu, Ding, Hou, Yu, Nie and Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic diagram highlighting the regulation of the cell differentiation by miR-130a-3p in MSCs. The miR-130a-3p secreted by MSCs directly binds to the 3′UTR of TGF-βRII, thereby down-regulating TGF-βRII and inhibiting the recruitment and activation of TGF-βRI, subsequently, phosphorylation of Smad2/3 is inhibited, and unable to form a complex with Smad4, which translocates to the nucleus to regulate gene transcription. MSC, mesenchymal stem cells; TGF-β1, transforming growth factor-β1; TGFBR2, transforming growth factor-β receptor II.