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. 2021 Aug 10;135(15):1915–1927. doi: 10.1042/CS20201453

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© 2021 The Author(s).

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).

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See the text. Klotho protein has a long amino-acid stretch designated as the receptor binding arm (RBA) that directly interacts with FGFRs. Modified from [6,8,51].