Figure 2.

Production of soluble integrin alpha 4 by exon skipping.

Integrin alpha 4 is encoded by the ITGA4 gene, which produces an mRNA consisting of 28 exons (upper left). Integrin alpha 4 is localized to the membrane (upper right) through a transmembrane domain that is encoded in exon 27 (upper left). The ASO-induced skipping of exon 27 yields an exon 27-deleted mRNA (lower left) that produces an integrin alpha 4 protein with a deleted transmembrane domain in a soluble form (lower right). The box and number in the box indicate the exon and its number.