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. 2021 Jul 28;9:703084. doi: 10.3389/fcell.2021.703084

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Copyright © 2021 Mitroshina, Savyuk, Ponimaskin and Vedunova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of HIF-mediated regulation of adaptive cell reactions. AKT1, the serine-threonine protein kinase AKT1; Bax, apoptosis regulator protein, also known as bcl-2-like protein 4; BNIP3, a member of the apoptotic Bcl-2 protein family; EPO, erythropoietin; GLUT-1, facultative glucose transporter 1; HIF, hypoxia-inducible factor; MCT4, monocarboxylate transporter 4; p53, pro-apoptotic transcription factor; PI3K, phosphoinositide 3-kinase; PHD, HIF prolyl hydroxylase; Ub, ubiquitin; VEGF, vascular endothelial growth factor; VHL, von Hippel–Lindau protein; vWF, von Willebrand factor.

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