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. 2020 Dec 15;70(9):1734–1745. doi: 10.1136/gutjnl-2020-321190

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Metric multidimensional scaling of neutralisation data (104 polyclonal immunoglobulins (pIg) samples and 13 viruses). (A) Two-dimensional neutralisation map (with no normalisation and 1/D_ij as weight). Viruses are drawn as coloured circles, pIg as coloured squares. (B) Magnification of central cluster. (C) Representation of only the viruses shows mapping to six neutralisation clusters. Clusters are enumerated in clockwise orientation, and reference virus for each cluster is given. (D) Phylogenetic tree of E1E2 amino acid sequences of the cell culture-derived HCV (HCVcc) screening viruses. Branches of the tree are coloured according to viral genotypes. Clouds around the virus strains are coloured according to neutralisation cluster.