TABLE 1.
Characteristics of the cohort upon initiation of the study (P1 PROOF).
| OSA severity | Normal | Moderate | Severe | P-value |
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| AHI/h n (%) | <15 n = 259 (47.2) | 15.0–29.9 n = 190 (34.6) | ≥30.0 n = 100 (18.2) | |
| Age (years ± SD) | 66.1 (0.8) | 66.1 (0.9) | 66.2 (1.0) | NS |
| Gender, n (%) | ||||
| Females | 184 (71) | 110 (57.9) | 40 (40) | <0.001 |
| Males | 75 (29) | 80 (42.1) | 60 (60) | |
| BMI kg/m2 (±SD) | 24.2 (3.8) | 25.7 (3.9) | 26.8 (3.9) | < 0.0001 |
| Waist circumference (cm) (±SD) | 97.2 (9.0) | 98.1 (9.3) | 101.1 (7.5) | <0.0001 |
| Hip circumference (cm) (±SD) | 82.8 (10) | 85.0 (11.7) | 91.2 (9.9) | <0.0001 |
| Hip/waist (±SD) | 0.85 (0.06) | 0.87 (0.10) | 0.91 (0.09) | <0.0001 |
| Epworth scale score (±SD) | 5.0 (3.8) | 5.7 (3.6) | 6.4 (3.4) | 0.001 |
| Fasting glucose g/L (±SD) | 0.97 (0.1) | 0.97 (0.1) | 0.99 (0.1) | 0.01 |
| Cholesterol g/L (±SD) | 2.34 (0.42) | 2.34 (0.37) | 2.35 (0.52) | NS |
| LDLc g/L (±SD) | 1.55 (0.38) | 1.53 (0.35) | 1.56 (0.45) | NS |
| HDLc g/L (±SD) | 1.84 (0.41) | 1.83 (0.44) | 1.75 (0.58) | NS |
| Triglycerides g/L (±SD) | 1.38 (0.68) | 1.37 (0.70) | 1.59 (0.93) | 0.001 |
| 24-h Systolic BP mmHg (±SD) | 115 (14) | 119 (14) | 122 (17) | 0.001 |
| 24-h Diastolic BP mmHg (±SD) | 73 (8) | 75 (9) | 77 (10) | 0.001 |
| Antihypertensive medication (%) | 91 (35.1) | 85 (44.7) | 51 (51) | <0.01 |
| Head fat mass* % (±SD) | 20.3 (1.8) | 20.5 (1.7) | 20.9 (1.8) | NS |
| Trunk fat mass* (%) (±SD) | 31.9 (8.9) | 32.5 (9.5) | 33.3 (9.8) | NS |
| Whole body fat mass* (%) (±SD) | 32.2 (8.5) | 31.5 (9.5) | 31.1 (9.5) | NS |
BMI, body mass index; HDLc, high density lipoprotrein cholesterol; LDLc, low density lipoprotein cholesterol; BP, blood pressure. *Body fat mass was measured using dual-energy X-ray absorptiometry.