REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Mouse monoclonal anti-CD9	Abcam	Cat# ab2215; RRID: AB_302894
Mouse monoclonal anti-CD81	Abcam	Cat# ab59477; RRID: AB_943630
Mouse monoclonal anti-CD63	Abcam	Cat# ab59479; RRID: AB_940915
Rabbit monoclonal anti-Calnexin	Abcam	Cat# 2692-1; RRID: AB_2259493
Rabbit polyclonal anti-TSG101	Absin	Vat# abs137904
Biological samples
Human plasma	Ruijin Hospital, Shanghai Jiao Tong University School of Medicine	ClinicalTrials.gov (trial ID: NCT03108677);
Chemicals, peptides, and recombinant proteins
Cytochrome C	Sigma-Aldrich	C2506; CAS: 9007-43-6
Myoglobin	Sigma-Aldrich	M0632; CAS: 100684-32-0
Sinapic acid	Sigma-Aldrich	85429; CAS: 530-59-6
α-Cyano-4-hydroxycinnamic acid	Sigma-Aldrich	70990; CAS: 28166-41-8
2,5-Dihydroxybenzoic acid	Sigma-Aldrich	149357; CAS: 490-79-9
Phosphotungstic acid	Adamas	17191B; CAS: 12067-99-1
Trifluoroacetic acid	Adamas	B81548A; CAS: 76-05-1
Acetonitrile	Merck	1.00030.4000; CAS: 75-05-8
Deposited data
Raw proteome data	This manuscript; ProteomeXchange; Mendeley Data;	PXD024072; https://doi.org/10.17632/r5snnfc89s.1
Experimental models: Cell lines
Human: 143B cell line	ATCC	CRL-8303
Human: HOS cell line	ATCC	CRL-1543
Human: MG63 cell line	ATCC	CRL-1427
Human: U2OS cell line	ATCC	HTP-96
Mouse: 3T3E1 cell line	ATCC	CRL-2593
Software and algorithms
Origin software	OriginLab	https://www.originlab.com/
Metaboanalyst 4.0	McGill University, Montreal, Canada	https://www.metaboanalyst.ca/
CorelDraw Graphics Suite software	Corel, Ottawa, Canada	https://www.coreldraw.com/en/product/coreldraw/
Flexanalysis	Bruker, Bremen, Germany	NA
Other
DMEM	Gibco	Cat# 11995065
FBS	Gibco	Cat# 10099141
Penicillin-streptomycin	Gibco	Cat# 15140-122
PBS	HyClone	Cat# SH30256.01
Trypsin	Gibco	Cat# 25200056
MEM Alpha	Gibco	Cat# 12641800