Table 3.
Association of IGFBPs with waist-to-height ratio in adolescents.
| Linear Regression | ||||||
|---|---|---|---|---|---|---|
| β1 | 95% CI | p | β2 | 95% CI | p | |
| IGFBP-1 (log) | -1.72 | -2.11, -1.33 | <0.001 | -1.72 | -2.07, -1.37 | <0.001 |
| IGFBP-3 | 86.13 | -301.12, 473.37 | 0.66 | 89.21 | -299.35, 477.78 | 0.65 |
| IGFPB-7 | 1.24 | -4.03, 6.50 | 0.65 | 1.19 | -4.08, 6.47 | 0.66 |
| Logistic Regression | ||||||
| OR1 | 95% CI | p | OR2 | 95% CI | p | |
| IGFBP-1 | ||||||
| Lower Tertile | 4.55 | 2.74, 7.56 | <0.001 | 5.70 | 3.26, 9.96 | <0.001 |
| Middle Tertile | 1.26 | 0.78, 2.03 | 0.35 | 1.44 | 0.87, 2.39 | 0.16 |
| Upper Tertile | 1.00 | Ref | 1.00 | Ref | ||
| IGFBP-3 | ||||||
| Lower Tertile | 1.05 | 0.62, 1.80 | 0.84 | 1.06 | 0.62, 1.80 | 0.84 |
| Middle Tertile | 1.06 | 0.62, 1.81 | 0.83 | 1.05 | 0.62, 1.80 | 0.85 |
| Upper Tertile | 1.00 | Ref | 1.00 | Ref | ||
| IGFBP-7 | ||||||
| Lower Tertile | 0.77 | 0.48, 1.23 | 0.28 | 0.77 | 0.48, 1.24 | 0.28 |
| Middle Tertile | 1.10 | 0.69, 1.76 | 0.68 | 1.11 | 0.69, 1.77 | 0.68 |
| Upper Tertile | 1.00 | Ref | 1.00 | Ref | ||
1Unadjusted.
2Adjusted for age categories and sex.
In linear regression, IGF binding protein (IGFBP) and WC/Ht ratio were used as continuous variables N= 419 (IGFBP-1), 332 (IGFBP-3) and 428 (IGFBP-7). IGFBP-1 was log-transformed for normality.
Odds Ratios (OR) were calculated using binary logistic regression in which the response variable (WC/Ht ratio) was categorized into non-obesogenic waist (WC/Ht ratio ≤ 0.5 and obesogenic waist (WC/Ht ratio > 0.5), with the normal non-obesogenic waist as the reference category.