Skip to main content
. 2021 Jul 28;12:698621. doi: 10.3389/fendo.2021.698621

Figure 5.

Figure 5

LAMA4 expression does not change following short term weight loss in humans with obesity. (A) Weight (kg) of human subjects before and 3 months post-surgery shown on left y-axis [(****) indicates p < 0.0001] and % of weight loss 3 months post-surgery is shown on right y-axis. Data are Means ± SD. (B) LAMA4 mRNA expression in sWAT biopsies of obese subjects pre-surgery and 3 months post-surgery, normalized to average of pre-surgery subjects. Pre-surgery (n=9), Post-surgery (n=9). (C) Density of extracellular LAMA4 as determined by raw integrated density signal over total area of signal in fixed sections of sWAT from obese subjects pre-surgery and 3 months post-surgery. Pre-surgery (n=9), Post-surgery (n=6). (D) Representative images of extracellular LAMA4 immunofluorescence staining from obese pre-surgery and post-surgery subjects. LAMA4 (in green) and DAPI (in blue). All images are 40X magnification.