Table 3.

Pooled results of secondary outcomes, pooled and grouped by type of intervention) measured in kilograms (kg) with standard error (SE).

	No. of Studies	Point estimates (kg) pre-post	SE	95% CI	p	I2 (%)
Pooled effect	58	−1.13	0.12	−1.36 to −0.90	P < 0.001	92.8
Discontinuation	33	−0.86	0.18	−1.34 to −0.38	P < 0.001
Dose reduction	7	−1.25	0.72	−2.66 to 0.17	P = 0.08
Switch to partial agonist	18	−1.57	0.19	−1.94 to −1.20	P < 0.001

95% Confidence intervals (95% CIs) and measure of heterogeneity (I²).