Table 2.
Cluster of the LDD-DR network.
| Cluster | Score | Nodes | Edges | Targets and genes |
|---|---|---|---|---|
| 1 | 79.229 | 110 | 4318 | PTEN, HMOX1, TLR4, MAPK14, IL17A, ACTB, GAPDH, IL4, IL10, CAT, HPGDS, HSPA4, MMP2, JUN, IFNG, NFKB1, MAP2K7, MAP2K1, CTNNB1, MDM2, IL1B, CXCR4, MAPK8, PCNA, PARP1, CASP3, CALM1, CALM2, CALM3, MAPK1, MAPK3, PTGS2, MAPK9, HSP90AA1, BCL2L1, NGF, CREB1, F3, IRS1, BCL2, LEP, STAT3, CD40LG, EGF, TNFSF10, CCL5, BAX, PLG, TF, IGF1R, MTOR, PIK3CG, KIT, HRAS, KITLG, FASLG, EGR1, ANXA5, RHOA, SPP1, AR, CASP1, TP53, CSF1, AKT1, TLR2, VIM, F2, GRB2, CDK2, CASP9, SRC, ESR1, ACE, EPO, TNFRSF1A, ICAM1, JAK2, ALB, PIK3CA, IGF1, FOS, CCL2, INS, IL13, FGF2, CYCS, NOS3, VCAM1, SERPINE1, BIRC5, CXCL12, MMP9, EGFR, KDR, TNF, SHC1, TGFB1, EDN1, PPARG, IL6, REN, CDC42, TIMP1, ABL1, SELE, IL2, BDNF, NR3C1, APOE |
| 2 | 23.271 | 119 | 1373 | HIF1A, BDKRB2, INSR, SELP, PIK3R1, CXCL10, NPY, TIMP3, TXN, XIAP, HBEGF, PGR, SSTR1, APLN, AHSG, BDKRB1, APLNR, IL1R1, PDGFRB, AKT2, IGF2, PF4, EP300, PTPN11, CNR1, CASP7, GGT1, SERPINA1, IL18, HNF4A, CYBB, CD40, HBA1, PDGFB, HSPA5, TNFRSF1B, CTLA4, STAT1, GAS6, PRKCA, PLAU, ALDOA, SIRT1, PXN, RPS6KB1, IL1A, ELN, VEGFB, CXCL9, RAF1, CCR2, S1PR1, SOCS3, CSF1R, CCL4, FOXO1, LIF, CCR5, APOH, CFD, HRG, SELL, IL2RA, VEGFC, CDKN3, FAS, PRL, SP1, SMAD3, PTGER3, MMP1, GNB3, KNG1, TMSB4X, CDK6, CORT, SERPINF2, C5AR1, MPO, PTK2, LCK, HCAR2, GSK3B, ITGAM, SMAD4, MCL1, HGF, CXCL5, SMAD2, CTGF, F8, PROS1, MET, FGB, A2M, MMP3, C5, TEK, TGFB2, AGTR1, AGTR2, FGG, NPY2R, SSTR3, SERPINA4, MMRN1, GFAP, VTN, ATM, SPARC, TLR9, ITGA2, CRP, CXCR3, SSTR2, HSPB1, NOS2, ECM1, VWF |
| 3 | 7.154 | 53 | 186 | GCG, JAK3, ANGPT1, HSPA8, MMP14, HSPA1A, HCK, CSK, THBS1, SOCS1, TIMP2, RAC2, EIF4E, PLAT, CD79A, SRF, ENG, APAF1, BMP4, PTPN1, SYK, ERBB4, IL6R, TNC, MMP13, SOD2, ELANE, MAP3K5, CD36, MMP7, PDGFA, AKT3, FADD, PRKCB, EIF4EBP1, FLT1, ETS1, PGF, AGT, CDH5, TJP1, MAPK12, IFNA2, FGFR1, FGF1, IGFBP3, CCL3, KAT2B, GJA1, FN1, ADIPOQ, BMP2, ITGA2B |
| 4 | 6.5 | 9 | 26 | NME2, ENTPD5, NT5M, IMPDH1, CANT1, LDHB, GMPR, GMPR2, APRT |
| 5 | 5.833 | 13 | 35 | ALDH2, TKTL1, MTHFR, GPI, UMPS, DHFR, G6PD, ACACB, ALDH1A1, IMPDH2, TXN2, SIRT6, PPP5C |
| 6 | 4.756 | 46 | 107 | EDN3, CTSS, PPARA, LPL, ANGPT2, GSR, OSM, BGLAP, F2RL2, F2RL1, CD209, SST, NOX4, BTK, UTS2, IGFBP1, MLN, IL2RB, S100B, EPOR, MAPK10, LYZ, CNTF, PRKCD, RAC1, RETN, FASN, OPN4, EDNRA, VDR, EDNRB, ITGAV, ITGB1, TNFRSF11B, CA2, SOD1, EDN2, NOX1, LGALS3, GHR, PRKCQ, APOB, HMGB1, CYBA, FLT4, ZAP70 |
| 7 | 4.4 | 16 | 33 | MTAP, SRR, SIRT5, AHCY, RHO, SDS, GLP1R, SIRT3, PYGL, AMY2A, SCT, ARF4, CBS, ADCYAP1, AMY1B, AMY1C |
| 8 | 4.286 | 15 | 30 | EPHB3, CRYZ, EPHB4, GART, GSTO1, HDAC8, KIF11, GSTA3, PPM1D, GSTM2, TCF7L2, GSTM1, ADH1B, GSTA1, SUV39H1 |
| 9 | 4 | 4 | 6 | CRABP2, RARG, RXRG, RARB |
| 10 | 3.9 | 21 | 39 | FKBP1A, NQO1, AMBP, IRF8, RUNX1, TYMS, RAB5A, MME, GPX1, PRKACA, MTHFD1, RAB11A, ENO2, PRDX1, RARA, HLA-A, PDIA3, PML, PRDX4, TPI1, LAMP1 |
| 11 | 3.333 | 4 | 5 | CD28, CD4, ITK, HLA-DRB1 |
| 12 | 3.333 | 4 | 5 | PDHB, TKT, AKR1B1, TXNRD2 |
| 13 | 3.333 | 4 | 5 | MAOA, AOC3, TPH1, MAOB |
| 14 | 3.25 | 17 | 26 | CD163, APOC3, AURKA, HMGCR, DUT, ADAM17, GLI1, GC, PRKAA2, APOA1, JAG1, ELAVL1, HPX, NAMPT, ATIC, CP, CCNA2 |
| 15 | 3 | 3 | 3 | GCK, H6PD, PKLR |
| 16 | 3 | 3 | 3 | ACAA1, ACADM, ACAT1 |
| 17 | 2.833 | 13 | 17 | CASP12, NRP1, TGFBR1, ITGA4, CTSB, XBP1, COL18A1, HSP90AB1, HSP90B1, ITGB3, ITGAL, PDPK1, ATF4 |
| 18 | 2.727 | 12 | 15 | CYP2C8, GDF15, CARM1, GSTZ1, CYP2C19, RND3, SULT2A1, NR1H2, RXRA, TGFBR2, CYP2C9, ACVRL1 |