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. 2021 Jul 28;11:706619. doi: 10.3389/fonc.2021.706619

Table 2.

The demographic characteristics of 291 patients in the study.

Variables Size of tumor P-Value
5–9.9 cm (n = 253) ≥ 10 cm (n = 38)
Age (y) 49.20 ± 11.16 48.75 ± 10.45 0.943
Gender 0.570
Male 85 (33.60%) 11 (28.95%)
Female 168 (66.40%) 27 (71.05%)
Comorbidities, N (%)
Gallbladder polyps 12 (4.74%) 3 (7.89%) 0.670
Hypertension 44 (17.39%) 9 (23.68%) 0.349
Type 2 diabetes mellitus 10 (3.95%) 2 (5.26%) 1.000
Hepatitis B/C 10 (3.95%) 3 (7.89%) 0.499
Hepatic cysts 11 (4.35%) 3 (7.89%) 0.577
Child-Pugh grading, N (%) 1.000
Glass A 246 (97.23%) 37 (97.37%)
Glass B 7 (2.77%) 1 (2.63%)
No. of tumor 0.868
Single lesion 241 (95.26%) 37 (97.37%)
Two lesion 12 (4.74%) 1 (2.63%)
Distribution of lesion, N (%) 0.074
Right lobe 134 (52.96%) 25 (65.79%)
Left lobe 78 (30.83%) 12 (31.58%)
Both 41 (16.21%) 1 (2.63%)
Reason for RFA, N (%) 0.003
Abdominal pain 73 (28.85%) 21 (55.26%)
Enlargement of hemangioma 101 (39.92%) 7 (18.42%)
Abdominal pain and enlargement hemangioma 79 (31.23%) 10 (26.32%)
Laboratory findings
Hb (g/L) 135.13 ± 15.87 130.55 ± 14.81 0.097
ALT (U/L) 21.42 ± 20.91 17.72 ± 8.10 0.289
AST (U/L) 23.78 ± 40.15 18.23 ± 4.14 0.659
TBil (μmol/L) 12.53 ± 5.20 13.90 ± 6.91 0.247
BUN (mmol/L) 4.95 ± 1.47 4.84 ± 1.23 0.614
Creatinine (μmol/L) 70.57 ± 36.30 65.33 ± 12.51 0.484
PT (s) 12.18 ± 1.33 12.87 ± 4.68 0.376
APTT (s) 31.38 ± 4.32 32.85 ± 6.65 0.074

Continuous variables are expressed by median ± standard deviation.

Hb, hemoglobin; TBil, total bilirubin; ALT, alanine aminotransferase; AST, aspartate transaminase; BUN, blood urea nitrogen.

PT, prothrombin time; APTT, activated partial thromboplastin time.

For the patients with multiple hepatic hemangiomas, the hepatic hemangiomas not managed were not included statistical range.