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. 2021 Jul 28;8:702370. doi: 10.3389/fmolb.2021.702370

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Copyright © 2021 Dall’Asta, Laghi, Morselli, Re, Zagonari, Patuelli, Foschi, Pedna, Sambri, Marangoni and Danesi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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rPCA model built on the centered and scaled concentrations of the metabolites showing significant differences based on Nugent score. In the scoreplot (A), the color of the dots (each representing a woman enrolled in the study) goes from green to red as the Nugent score increases. Y-axis shows Nugent score values. In the barplot (B), describing the correlation between the concentration of each molecule and its importance over PC1, dark grey bars highlight statistically significant correlations (p < 0.05).