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. 2021 Jul 28;9:695139. doi: 10.3389/fpubh.2021.695139

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Copyright © 2021 Logette, Lorin, Favreau, Oshurko, Coggan, Casalegno, Sy, Monney, Bertschy, Delattre, Fonta, Krepl, Schmidt, Keller, Kerrien, Scantamburlo, Kaufmann and Markram.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Simplified computational model of SARS-CoV-2 replication rate as a function of glucose concentration in the ASL and viral load at time of a sneeze stimulus. (A) The dynamic of the viral replication, in case of three different viral load (low, intermediate, and high, see section Methods), as a function of a sweep over a range of glucose concentrations in ASL was computed and represented. (B) The values of viral replication rate in a normoglycemic (0.4 mM ASL glucose) or hyperglycemic case (1.2 mM ASL glucose) after a low, intermediate, or high viral load at time of infection are deduced from the model [see dashed line in (A)] and plotted.