Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No description of random sequence generation was provided.
Allocation concealment (selection bias)	Unclear risk	No description of allocation concealment was provided.
Blinding of participants and personnel (performance bias)	High risk	Blinding of participants and personnel was not possible due to the nature of the intervention and study design.
Blinding of outcome assessment (detection bias)	Unclear risk	No description of blinding of outcome assessment was provided.
Incomplete outcome data (attrition bias)	Unclear risk	No description of reporting outcome data incompletely or attrition bias was provided.
Selective reporting (reporting bias)	Low risk	No evidence of reporting outcomes selectively was detected.
Other bias	Low risk	No other potential biases detected.