Study name	Effect of probiotic supplementation on feed tolerance and weight gain in low birth weight infants on tube feeds
Methods	Randomized, parallel group trial
Participants	Inclusion criteria: All neonates with a birth weight between 1000 and 1800 gm admitted to the NICU in whom enteral feeds can be started.
	Exclusion criteria:
	Neonates with weight <1000 gm
	Neonates with gastrointestinal anomalies
	Neonates with major congenital malformations
	Neonates in whom the feed could not be started by day 14 of life
Interventions	Intervention 1: Probiotic: Probiotic containing Lactibacillus acidophilus, Lactibacillus rhamnosus, Bifidobacterium longum, Saccharomyces boulardi in form of powdered sachet of 1 g each
	Control Intervention 1: Nil: Nil
Outcomes	To compare the time taken (in days) to reach full enteral feeds (150 ml/kg/day) in low birth weight infants on orogastric feeds between the probiotic and no probiotic group
	To compare episodes of feed intolerance and weight gain in both the groups.Timepoint: Time taken to reach full enteral feeds
Starting date	31‐07‐2018
Contact information	Neonatal Intensive Care Unit, Department of pediatrics,GGS medical college and hospital faridkot
	Faridkot
	PUNJAB
	151203
	India
	dr.amarpreet12@gmail.com
Notes