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. 2021 Mar 5;17(1):e1141. doi: 10.1002/cl2.1141
Methods A randomized double‐blind controlled trial conducted in South Africa in community settings
Participants Inclusion criteria: "healthy", full term (37–42 weeks), born to HIV + formula feeding mothers, ≤3 days old, 2500–4500 g, singleton birth
Exclusion criteria: Congenital illness or malformation affecting growth; significant perinatal disease, antibiotics in 1st 3 days of life, caregivers could not comply, or in another trial
Interventions Intervention: Probiotics: Formula containing prebiotic (bovine milk‐derived oligosaccharides) and probiotic ((B. lactis strain CNCM‐I‐3446 with 1 × 107 cfu/g. of powder formula). The duration of intervention was 6 months
Comparison: Formula without prebiotic and probiotic
Outcomes All‐cause mortality
Notes The data was taken from the last paragraph of the result section. We note that the intervention group received both prebiotics and probiotics and the control group did not receive any prebiotics or probiotics. Some of the study participants were HIV positive