Methods
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A randomized double‐blind controlled trial conducted in South Africa in community settings |
Participants
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Inclusion criteria: "healthy", full term (37–42 weeks), born to HIV + formula feeding mothers, ≤3 days old, 2500–4500 g, singleton birth |
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Exclusion criteria: Congenital illness or malformation affecting growth; significant perinatal disease, antibiotics in 1st 3 days of life, caregivers could not comply, or in another trial |
Interventions
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Intervention: Probiotics: Formula containing prebiotic (bovine milk‐derived oligosaccharides) and probiotic ((B. lactis strain CNCM‐I‐3446 with 1 × 107 cfu/g. of powder formula). The duration of intervention was 6 months |
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Comparison: Formula without prebiotic and probiotic |
Outcomes
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All‐cause mortality |
Notes
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The data was taken from the last paragraph of the result section. We note that the intervention group received both prebiotics and probiotics and the control group did not receive any prebiotics or probiotics. Some of the study participants were HIV positive |