Methods	Prospective, randomized, controlled trial conducted in TurkeyQuote
Participants	Inclsuin criteria:: "VLBW infants with a gestational age of <32 weeks and a birth weight of <1500 g, born at or transferred to the NICU within the 1st week of life and fed enterally before inclusion, were eligible
	Exclusion criteria: Infants with any disease other than those linked to prematurity or congenital anomalies of the intestinal tract, not fed enterally or who died before the seventh day after birth, whose mothers had taken nondietary probiotic supplements, and whose parents refused to participate were excluded"
Interventions	Intervention: Probitics/Prebiotics
	Multiple Arm trial
	1)Probiotic (Bifiidobacterium lactis, 5×109 colony‐forming units) 2)Prebiotic (inulin, 900 mg) 3)Synbiotic (Bifidobacterium lactis, 5×109 colony‐forming units, 30 mg plus inulin, 900 mg 4) The control group: maltodextrin powder as a placebo
	The dose was 1 sachet per day of pre/probiotics with breast milk or formula until discharge or death, for a maximum of 8 weeks, whichever comes first
Outcomes	NEC, sepsis and mortality
Notes	The data were taken from table 3. We included data as probiotics+synbiotics vs. prebiotics+placebo