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. 2021 Mar 5;17(1):e1141. doi: 10.1002/cl2.1141
Methods Prospective randomized control trial conducted in Iran
Participants Inclusion Criteria: "All premature newborns (n = 115) weighting 750–1500 g or <32 weeks' gestation who received antibiotics and total parenteral nutrition in NICU of Vali Asr Hospital were included"
Exclusion Criteria: "Premature babies <750 and more than 1500 g and neonates with congenital heart disease, congenital malformations, and immune system deficiency, even in their family members, were excluded from the study."
Interventions Intervention: Multistrain powder probiotic infant formula containing Streptococcus thermophilus, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Bifidobacterium infantis, Lactobacillus casei. The dose was 0.8–1 g per day in 8–10 doses given for 13 days
Comparison: Enteral feed without probiotic
Outcomes NEC
Notes Data were taken from table 3