| Methods | Propsective, double‐blind, randomized clinical trial conducted in Mexico |
| Participants | Inclusion criteria: Preterm newborns who weighed <1500 g admitted at the intensive and intermediate care units |
| Exclusion criteria: Preterm newborns weighing <1500 g with a low Apgar score (<6 at 5 min), gastrointestinal malformations, genetic syndromes, asphyxia and IA–IB NEC stages according to Bell's | |
| Interventions | Intervention: Probiotic supplementation: "Lacidophilus 1.0×109 colony forming units (CFU) CFU/g, Lactobacillus rhamnosus 4.4×108 CFU/g, Lactobacillus casei 1.0×109 CFU/g, Lactobacillus plantarum 1.76×108 CFU/g, Bifidobacteruim infantis 2.76×107 CFU/g, Streptococcus theremophillus 6.6×105 CFU/g, each pack (Laboratorio Italmex SA)" |
| Control: "The control group received their regular feeds from their mother's own milk when available with nothing added, or a premature infant formula" | |
| Outcomes | All‐cause mortality, NEC |
| Notes | Data were taken from table 3 |