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. 2021 Mar 5;17(1):e1141. doi: 10.1002/cl2.1141
Methods Propsective, double‐blind, randomized clinical trial conducted in Mexico
Participants Inclusion criteria: Preterm newborns who weighed <1500 g admitted at the intensive and intermediate care units
Exclusion criteria: Preterm newborns weighing <1500 g with a low Apgar score (<6 at 5 min), gastrointestinal malformations, genetic syndromes, asphyxia and IA–IB NEC stages according to Bell's
Interventions Intervention: Probiotic supplementation: "Lacidophilus 1.0×109 colony forming units (CFU) CFU/g, Lactobacillus rhamnosus 4.4×108 CFU/g, Lactobacillus casei 1.0×109 CFU/g, Lactobacillus plantarum 1.76×108 CFU/g, Bifidobacteruim infantis 2.76×107 CFU/g, Streptococcus theremophillus 6.6×105 CFU/g, each pack (Laboratorio Italmex SA)"
Control: "The control group received their regular feeds from their mother's own milk when available with nothing added, or a premature infant formula"
Outcomes All‐cause mortality, NEC
Notes Data were taken from table 3