Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Quote: "Subjects were allocated to the groups by a third party using a simple alternating randomization technique"
		Comment: Alternation allocation of patients is not random
Allocation concealment (selection bias)	Unclear risk	Quote: "Subjects were allocated to the groups by a third party using a simple alternating randomization technique"
		Comment: It is not clear if the allocation was revealed before the patient were allocated to intervention or placebo
Blinding of participants and personnel (performance bias)	Unclear risk	Authors mentioned that it was a double blind trial but no details were provided on how the blinding was done
Blinding of outcome assessment (detection bias)	Unclear risk	Authors mentioned that it was a double blind trial but no details were provided on how the blinding was done
Incomplete outcome data (attrition bias)	Low risk	No attrition was reported
Selective reporting (reporting bias)	Unclear risk	Authors seem to report all the relevant outcomes
Other bias	Unclear risk	No other risk of bias was noted