Methods
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A randomized double‐blind placebo‐controlled trial India |
Participants
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Inclusion Criteria: Inborn, VLBW (birth weight (BW) < 1500 g) neonates admitted in NICU and requiring respiratory support in the form of oxygen inhalation through nasal prongs or head box, continuous positive airway pressure (CPAP), high flow nasal cannula (HFNC), or mechanical ventilation (MV) at the age of 24 h, were included. |
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Exclusion Criteria: Neonates with major congenital malformation, any life‐threatening condition such as reversal of umbilical artery end‐diastolic blood flow on antenatal Doppler, perinatal asphyxia with moderate to severe hypoxic ischemic encephalopathy, shock with escalating doses of vasopressors, recurrent seizures, and suspected inborn errors of metabolism |
Interventions
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Intervention: 10,000 IU of retinol/dose, alternate days, 28 days or until discharge |
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Compairson: Placebo |
Outcomes
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All‐cause mortality, sepsis, NEC |
Notes
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Study conducted in very low birth weight babies |