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. 2021 Mar 5;17(1):e1141. doi: 10.1002/cl2.1141
Methods A multicenter, double‐blinded, randomized, placebo‐controlled trial conducted in Colombia
Participants Inclusion Cciteria: "Preterm infants admitted to NICU, birth weight ≤ 2000 g, haemodynamically stable (blood pressure not requiring boluses or pressors), and ≤ 48 h of age"
Exclusion criteria: "Infants with evidence or suspicion of congenital intestinal obstruction or perforation, gastroschisis, large omphalocele, congenital diaphragmatic hernia, major congenital heart defects, or anticipated transfer to a NICU not participating in the study were excluded"
Interventions Intervention: Probiotic administration:"Infants in the probiotic group received 5 drops of an oil‐based suspension containing 108 colony‐forming units of L reuteri DSM 17938"
Comparison: Oil based placebo
Outcomes Mortality, NEC
Notes Data were taken from table 2. The duration of the intervention was not clearly stated