Methods
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A prospective, triple blind, placebo controlled trial conducted in Iran |
Participants
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Inclusion criteria: "premature infants admitted at the neonatal intensive care unit (NICU) during October 2012‐March 2013. Gestational age of infants was estimated at 28–34 weeks using the Dubowitz method, and birth weight of infants was calculated to be 1000–1800 g" |
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Exclusion criteria: "presence of disorders such as digestive obstruction, GI bleeding, gastroschisis, omphalocele, withdrawal syndrome, neonatal proven or clinical sepsis, congenital heart defect and asphyxia (degree II or III)" |
Interventions
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Intervention: "5 ml of a mixture containing Lactobacillus reuteri DSM 17938. One drop of this product holds a minimum of 20 million live Lactobacillus reuteri protectis." The intervention was given two times daily. The intervention was given until the child achieved full enteral feedings |
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Control: "placebo group received 0.5 ml of distilled water every 12 hours" |
Outcomes
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Mortality, sepsis, NEC |
Notes
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Data were taken from table 2 |