Methods | A double blind randomized controlled trial in India |
Participants | Inclusion criteria: "All neonates with a birth weight between 750 and 1499 g admitted to the NICU" |
Exclusion criteria: "Neonates with gastrointestinal anomalies, severe congenital malformation, and those not started on enteral feeds by day 14 of life were excluded" | |
Interventions | Intervention: "Multicomponent probiotic formulation of Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium longum, and Saccharomyces boulardii in the form of powdered sachets of 1 g each. The intervention was administered once a day at a dose of 1.25×109 CFU starting within 24 h of initiation of feeds. The probiotic supplementation was continued till discharge given once a day if the volume of feeds was 2 ml or more, and in two divided doses if the baby received <2 ml/feed |
Control: "The no probiotic group received only breast milk and served as the control" | |
Outcomes | Mortality, NEC |
Notes | Data were taken from table 2 |