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. 2020 May 18;16(2):e1085. doi: 10.1002/cl2.1085
Review article Target population Intervention reviewed HIC or LIC Last search date Primary outcomes Secondary outcomes No. of studies Sub group analysis Quality assessment

Meta‐analysis

MD (95% CI)

Salam Rehana et al. (2016) Adolescents (11–19 years) and Youth (15–24 years) Micronutrient supplementation Global December 2014 Outcomes were not prespecified so all the outcomes reported by the study authors were included Outcomes were not prespecified 31 School setting Cochrane risk of bias assessment tool Impact of Iron‐folic acid supplementation on anaemia RR = 0.69(0.62, 0.76)
Salam Rehana et al. (2016) Pregnant Adolescents Micronutrient supplementation Global December 2014 Outcomes were not prespecified so all the outcomes reported by the study authors were included Outcomes were not prespecified 16 Not mentioned Cochrane risk of bias assessment tool Impact of nutrition interventions on
Nutritional education Mean birth weight SMD = 0.25(0.08,0.41)
Low birth weight RR = 0.70(0.57, 0.84)
Lassi Zohra et al. (2017) Adolescents (10–19 years) and Women of reproductive age Micronutrient supplementation Global October 2016 Mortality, pregnancy outcomes, morbidity, nutritional, anthropometrics 107 Family based interventions GRADE Working Group grades of evidence Iron supplementation vs. placebo:
Food/protein energy supplementation
Nutrition education for pregnant adolescents Hemoglobin concentration (g/L) in adolescents: SMD = 1.83(0.59, 3.08)
Obesity prevention IFA supplementation vs. placebo:
Hemoglobin (g/L) in adolescents: MD = 2.24(0.36, 4.12)
Management of gestational diabetes Vitamin D supplementation vs. placebo
25(OH)D (nmol/L) concentration in adolescents: MD = 8.80(−2.68, 20.28)
Zinc supplementation vs. placebo:
Hemoglobin (g/L) concentration in adolescents: SMD = 4.81(0.97, 8.66)
Serum zinc (mol/L) in adolescents: SMD = 4.28(2.49, 6.06)
Preterm birth in pregnant adolescents: RR = 0.57(0.46, 0.69)
Low birth weight in pregnant adolescents: RR = 0.39(0.15, 0.98)
Iodine supplementation vs. placebo:
TSH (U/dL) concentration in adolescents:.SMD = 0.25(−0.02, 0.52)
Interventions for prevention of obesity in pregnant adolescent: birth weight: SMD = −0.05(−0.11, 0.01)
Interventions for management of obesity in adolescents: BMI:
SMD = −0.24(−0.36, −0.13)
Hoyland, Dye and Lawton (2009) Children or adolescent (aged 18 years) Any type of breakfast manipulation Global January 2009 Outcome measures of cognitive performance 45 Not mentioned JADAD criteria used Not performed
Meiklejohn, Ryan and Palermo (2016) Adolescents aged 18 years Nutrition education was delivered in conjunction with complementary strategies High and Middle Income Countries September 2014 Anthropometric measures, biochemical markers, dietary consumption data, changes in dietary intake of fruits and vegetables, snack foods, fat, sucrose, sugar‐sweetened beverages and soft drinks 13 Not mentioned American Dietetics Association. ADA Not performed
Evidence Analysis Manual, IV ed
Das et al. (2013) Children and adolescent till age of 18 years and women of reproductive age Fortification Global November 2012 Serum micronutrient levels, hematologic markers, anthropometric indicators, pregnancy outcomes, morbidity outcomes, mortality 201 Age groupsCountries GRADE Working Group grades of evidence Results for iron fortification in children
Hemoglobin levels: SMD = 0.55 (0.34, 0.76)
Population characteristics Effect on anaemia: RR = 0.55 (0.42, 0.72)
Type of food fortified Results for zinc fortification in children
Duration of intervention Serum zinc levels: SMD = 1.28 (0.56, 2.01)
Hemoglobin level: SMD = −0.11(−0.52, 0.31)
Copper Levels: SMD = 0.57 (−0.91, 2.06)
Serum alkaline phosphatase levels: SMD = 0.94(−0.29, 2.17)
Weight gain: SMD = 0.50(−0.12, 1.11)
Height growth: SMD = 0.52 (0.01, 1.04)
Calcium and vitamin D fortification
Serum parathyroid hormone levels:SMD = −0.40 (−0.56,−0.24)
Serum vitamin D levels: SMD = 1.23 (0.35,2.11)
Serum calcium levels:SMD = −0.40 (−0.59,−0.20)
Results for multiple micronutrient fortification in children
Hemoglobin levels: SMD = 0.75(0.41, 1.08)
Effect on anaemia: RR: 0.55 (0.42, 0.71)
Effect on vitamin A deficiency: RR = 0.90 (0.76, 1.06)
Height‐for age Z‐score: SMD: 0.13(−0.04, 0.29)
Weight‐for age Z‐score: SMD: −0.12(−0.43, 0.20)
Weight‐for height Zscore:SMD: −0.11(−0.40, 0.17)
Results for iron, folate and calcium/vitamin D fortification in women
Hemoglobin levels: SMD: 0.62 (0.36,0.89)
Effect on anaemia: RR: 0.68 (0.49, 0.93)
Marquez, Racey, Preyde, Hendrie and Newton (2015) Adolescents aged 12 to 18 years Interventions targeting an increase in dairy food or Calcium intake Global February 2015 Intakes of calcium, milk and dairy per day 16 Not mentioned The Quality Not performed
Assessment Tool for Quantitative Studies
by EPHPP
Samuelson 2017 Adolescents aged 10–19 years Diet and nutrition interventions Global January 2016 Depression 11 Not mentioned Not mentioned Not performed
Lohner et al. (2012) Children and adolescents Folate supplementation Global March 2009 Serum folate content, erythrocyte folate content 26 Not mentioned Not mentioned Not performed