Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: Insufficient information to permit judgement
Allocation concealment (selection bias)	Unclear risk	Comment: Insufficient information to permit judgement
Blinding of participants and personnel (performance bias)	High risk	Comment: Probably not done
Blinding of outcome assessment (detection bias)	Unclear risk	Comment: Insufficient information to permit judgement
Incomplete outcome data (attrition bias)	Low risk	Comment:
		Group 1: No loss to follow up
		Group 2: 1/60 loss to follow‐up
		Group 3: 7/60 loss to follow‐up
Selective reporting (reporting bias)	Unclear risk	Comment: Trial registration not reported. Outcomes specified in the methodology section were reported
Other bias	Low risk	Comment: No other biases detected.